The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may end in a rise in methadone plasma concentrations, which could result in possibly fatal respiratory depression. Also, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may also end in a rise in methadone pl